| Identification | Back Directory | [Name]
AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2 | [CAS]
188530-20-3 | [Synonyms]
Ac-AE-Asp(EDANS)-EE-Abu-L-lactoyl-S-Lys(DABCYL)-NH2
AC-ASP-GLU-ASP(EDANS)-GLU-GLU-ABU-L-LACTOYL-SER-LYS(DABCYL)-NH2
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-L-lactoyl-Ser-Lys(DABCYL)-NH2 ammonium salt
N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-(2S)-2-aminobutanoyl-(2S)-2-hydroxypropanoyl-L-seryl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-L-lysinamide
L-Lysinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-(2S)-2-aminobutanoyl-(2S)-2-hydroxypropanoyl-L-seryl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]- | [Molecular Formula]
C68H89N15O25S | [MDL Number]
MFCD01318843 | [MOL File]
188530-20-3.mol | [Molecular Weight]
1548.58 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [pka]
-0.26±0.40(Predicted) | [Sequence]
Ac-Asp-Glu-{Asp(Edans)}-Glu-Glu-Abu-{ψ-(COO)Ala}-Ser-{Lys(Dabcyl)}-NH2 |
| Hazard Information | Back Directory | [Uses]
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 355/500 nm.) |
|
|