1886-26-6

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1886-26-6 Structure

Identification	Back Directory
[Name] Norfenfluramine
[CAS] 1886-26-6
[Synonyms] α-Methyl-m-(trifluoromethyl)phenethylamine 1-[3-(Trifluoromethyl)phenyl]-2-aminopropane [1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine
[Molecular Formula] C10H12F3N
[MDL Number] MFCD00871809
[MOL File] 1886-26-6.mol
[Molecular Weight] 203.2

Hazard Information	Back Directory
[Uses] Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2].
[Definition] ChEBI: 1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines.
[References] [1] Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. DOI:10.1124/jpet.103.049684 [2] Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. DOI:10.1007/s11064-021-03358-2

Safety Data	Back Directory
[Toxicity] LD50 intraperitoneal in mouse: 51mg/kg

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