| Identification | Back Directory | [Name]
Norfenfluramine | [CAS]
1886-26-6 | [Synonyms]
α-Methyl-m-(trifluoromethyl)phenethylamine
1-[3-(Trifluoromethyl)phenyl]-2-aminopropane
[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine | [Molecular Formula]
C10H12F3N | [MDL Number]
MFCD00871809 | [MOL File]
1886-26-6.mol | [Molecular Weight]
203.2 |
| Hazard Information | Back Directory | [Uses]
Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2]. | [Definition]
ChEBI: 1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines. | [References]
[1] Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. DOI:10.1124/jpet.103.049684
[2] Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. DOI:10.1007/s11064-021-03358-2 |
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