| Identification | Back Directory | [Name]
4-methyl-2-chloro-pyrimidine-5-carboxylic acid | [CAS]
188781-10-4 | [Synonyms]
5-Carboxy-2-chloro-4-methylpyrimidine
4-ethyl-2-hydroxy-pyrimidine-5-carboxylic acid
2-chloro-4-methyl-5-Pyrimidine carboxylic acid
4-methyl-2-chloro-pyrimidine-5-carboxylic acid
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI)
5-Carboxy-2-chloro-4-methylpyrimidine, 2-Chloro-4-methyl-1,3-diazine-5-carboxylic acid | [Molecular Formula]
C6H5ClN2O2 | [MDL Number]
MFCD09863167 | [MOL File]
188781-10-4.mol | [Molecular Weight]
172.57 |
| Chemical Properties | Back Directory | [Boiling point ]
375.3±22.0 °C(Predicted) | [density ]
1.479±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder | [pka]
2.06±0.25(Predicted) | [color ]
Faint yellow |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-chloro-4-methylpyrimidine-5-carboxylic acid from ethyl 4-methyl-2-chloropyrimidine-5-carboxylate is as follows:
Example 9: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (1.0 g, 5 mmol) was reacted with an aqueous solution (30 mL) of NaOH (0.24 g, 6 mmol) with stirring at room temperature for 3 hours. After completion of the reaction, the reaction solution was acidified with 6N HCl and the precipitated solid was filtered and dried to afford 2-chloro-4-methylpyrimidine-5-carboxylic acid (0.67 g, 78% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.01 (s, 1H), 2.75 (s, 3H). | [References]
[1] Journal of medicinal chemistry, 2000, vol. 43, # 21, p. 3995 - 4004
[2] Patent: US5935966, 1999, A
[3] Patent: US5811428, 1998, A |
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