| Identification | Back Directory | [Name]
EPZ 025654 | [CAS]
1888328-89-9 | [Synonyms]
EPZ 025654
GSK 35336023)
EPZ-025654 HCl
EPZ 025654
(EPZ025654
2-Propanol, 1-[3-[4-[2-(1-azetidinyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-2-pyrimidinyl]-4-chlorophenoxy]-3-(methylamino)-, (2R)-
EPZ-025654 (R)-1-(3-(4-(2-(Azetidin-1-yl)-5,7-dihydro-6H-pyrrolo[3,4-
d]pyrimidin-6-yl)-6-(3,5-dimethylisoxazol-4-yl)-5-
methylpyrimidin-2-yl)-4-chlorophenoxy)-3-
(methylamino)propan-2-ol | [Molecular Formula]
C29H33ClN8O3 | [MOL File]
1888328-89-9.mol | [Molecular Weight]
577.08 |
| Hazard Information | Back Directory | [Description]
EPZ-025654 is a potent and selective arginine methyltransferase CARM1 inhibitor. | [Uses]
EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC50 of 3 nM[1]. | [IC 50]
PRMT6: 3 nM (IC50) | [References]
[1] Li ASM, et al., Chemical probes for protein arginine methyltransferases. Methods. 2020 Mar 15;175:30-43. DOI:10.1016/j.ymeth.2019.11.017 |
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