| Identification | Back Directory | [Name]
MNK inhibitor 9 | [CAS]
1889336-59-7 | [Synonyms]
MNK inhibitor 9
4-Pyridinecarboxamide, 2-[5-amino-6-[1-methyl-7-[(3S)-3-methyl-1-piperazinyl]-1H-benzimidazol-2-yl]-2-pyrazinyl]-N,N-dimethyl- | [Molecular Formula]
C25H29N9O | [MOL File]
1889336-59-7.mol | [Molecular Weight]
471.56 |
| Chemical Properties | Back Directory | [Boiling point ]
773.4±70.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.90±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 μM and 0.003 μM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research[1]. | [IC 50]
MNK1: 0.003 μM (IC50); MNK2: 0.003 μM (IC50) | [References]
[1] Han W, et al. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. J Med Chem. 2016 Apr 14;59(7):3034-45. DOI:10.1021/acs.jmedchem.5b01657 |
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