| Identification | Back Directory | [Name]
5-Pyrimidinecarboxylic acid, 4-[(2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrol-1-yl)amino]-2-(trifluoromethyl)-, ethyl ester | [CAS]
188936-12-1 | [Synonyms]
AP-1/NF-κB activation inhibitor 1
5-Pyrimidinecarboxylic acid, 4-[(2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrol-1-yl)amino]-2-(trifluoromethyl)-, ethyl ester | [Molecular Formula]
C13H11F3N4O4 | [MDL Number]
MFCD32874138 | [MOL File]
188936-12-1.mol | [Molecular Weight]
344.25 |
| Chemical Properties | Back Directory | [Boiling point ]
393.5±52.0 °C(Predicted) | [density ]
1.541±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
0.03±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1]. | [References]
[1] Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;1 DOI:10.1016/s0960-894x(00)00312-7 |
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