| Identification | Back Directory | [Name]
CEP-1612 | [CAS]
189036-01-9 | [Synonyms]
CEP-1612
UNII-9K6U075027
2H-Isoindole-2-decanamide, α-cyclopentyl-N-[(1S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]-1,3-dihydro-1,3-dioxo- | [Molecular Formula]
C35H53N7O7 | [MOL File]
189036-01-9.mol | [Molecular Weight]
683.85 |
| Hazard Information | Back Directory | [Uses]
CEP1612 is a dipeptidyl proteasome inhibitor with the IC50 of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo[1][2]. | [References]
[1] An B, et al. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ. 1998;5(12):1062-1075. DOI:10.1038/sj.cdd.4400436
[2] Sun J, et al. CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. Cancer Res. 2001;61(4):1280-1284. PMID:11245420 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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