| Identification | Back Directory | [Name]
2-Pyrimidinamine, N-[trans-4-[2-(4-phenyl-1-piperazinyl)ethyl]cyclohexyl]- | [CAS]
189152-50-9 | [Synonyms]
2-Pyrimidinamine, N-[trans-4-[2-(4-phenyl-1-piperazinyl)ethyl]cyclohexyl]- | [Molecular Formula]
C22H31N5 | [MOL File]
189152-50-9.mol | [Molecular Weight]
365.52 |
| Hazard Information | Back Directory | [Description]
Pd 158771 is a D2 and 5-HT1A agonist. | [Uses]
PD 158771 is an antipsychotic agent that functions as a partial agonist for D2 /D3 receptors (Ki = 42.0/13.7 nM) and as an agonist for 5-HT1A receptors (Ki = 2.6 nM). PD 158771 can be utilized in antipsychotic research[1]. | [IC 50]
hD2 Receptor: 42 nM (Ki); Human D3 Receptor: 13.7 nM (Ki); human 5-HT1A Receptor: 2.6 nM (Ki) | [References]
[1] Akunne HC, et al. PD 158771, a potential antipsychotic agent with D(2)/D(3) partial agonist and 5-HT(1A) agonist actions. I. Neurochemical effects. Neuropharmacology. 2000 Apr 27;39(7):1197-210. DOI:10.1016/s0028-3908(99)00224-5 |
|
|