| Identification | Back Directory | [Name]
10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one | [CAS]
18920-47-3 | [Synonyms]
CS-1215
ACH126447
Helioxanthin
Helioxanthin, ACH 126447
10-(1,3-Benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one
Furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9H)-one, 10-(1,3-benzodioxol-5-yl)- | [Molecular Formula]
C20H12O6 | [MDL Number]
MFCD28167790 | [MOL File]
18920-47-3.mol | [Molecular Weight]
348.31 |
| Chemical Properties | Back Directory | [Melting point ]
240-241 °C | [Boiling point ]
622.5±55.0 °C(Predicted) | [density ]
1.528±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Helioxanthin (ACH126447) has in vitro antiviral activity with an EC50 of 1 μM against HBV and is also active against flaviviruses. | [Definition]
ChEBI: Helioxanthin is a furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses. It has a role as an anti-HBV agent, a plant metabolite and an antineoplastic agent. It is a member of benzodioxoles, a furonaphthodioxole and a lignan. | [Biological Activity]
helioxanthin (ach126447) is a novel inhibitor of hbv, hcv and hsv-1 virus with ec50 values of 1 μm, 3 μm and 2 μm, respectively [1].helioxanthin has shown significant antiviral effect on hbv, hcv and hsv-1 virus in vitro with ec50 values of 1 μm, 3 μm and 2 μm, respectively. in a cell culture model, the level of hbv rna, the expression of hbv antigen and its replication were all reduced by helioxanthin. besides, helioxanthin has been exhibited to have a low cytotoxicity on both mt-223 and cem24 cell lines with id50 values of 2.5 μm and 31 μm, respectively [1]. | [References]
[1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46. |
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Cckinase, Inc.
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