| Identification | Back Directory | [Name]
AC-WEHD-CHO | [CAS]
189275-71-6 | [Synonyms]
AC-WEHD-CHO
AC-WEHD-ALDEHYDE
Ac-Trp-Glu-His-Asp-al
AC-TRP-GLU-HIS-ASP-CHO
CASPASE-INHIBITOR VIII
CASPASE-1 INHIBITOR VIII
N-Acetyl-Trp-Glu-His-Asp-al
AC-TRP-GLU-HIS-ASP-ALDEHYDE
AC-WEHD-CHO TRIFLUOROACETATE
CASPASE-1 INHIBITOR (ALDEHYDE)
N-ACETYL-TRP-GLU-HIS-ASPARTINAL
Acetyl-tryptyl-glutamyl-histidyl-aspartal
AC-TRP-GLU-HIS-ASP-H (ALDEHYDE) TRIFLUOROACETATE
ACETYL-L-TRYPTOPHYL-L-GLUTAMYL-L-HISTIDYL-L-ASPART-1-AL-TRIFLUOROACETATE
L-Histidinamide, N-acetyl-L-tryptophyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- | [Molecular Formula]
C28H33N7O9 | [MDL Number]
MFCD01318860 | [MOL File]
189275-71-6.mol | [Molecular Weight]
611.6 |
| Chemical Properties | Back Directory | [Boiling point ]
1250.2±65.0 °C(Predicted) | [density ]
1.434±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
H2O: 1 mg/mL | [form ]
powder | [pka]
4.17±0.10(Predicted) | [color ]
white | [Sequence]
Ac-Trp-Glu-His-{Asp-Aldehyde} |
| Hazard Information | Back Directory | [Uses]
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2]. | [IC 50]
Caspase-1: 56 pM (Ki) | [References]
[1] Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. DOI:10.1016/j.chembiol.2010.07.011
[2] Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55. DOI:10.1016/s1074-5521(97)90258-1 |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
|