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1895934-61-8

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1895934-61-8 Structure

1895934-61-8 Structure
IdentificationBack Directory
[Name]

HPO-DAEE
[CAS]

1895934-61-8
[Synonyms]

HPO-DAEE
Hazard InformationBack Directory
[Uses]

HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways[1].
[References]

[1] Inoue Y, et al. 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways. Neurochem Int. 2018 Jan;112:288-296. DOI:10.1016/j.neuint.2017.08.011
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