| Identification | Back Directory | [Name]
FR-188582 | [CAS]
189699-82-9 | [Synonyms]
FR-188582
1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl- | [Molecular Formula]
C16H13ClN2O2S | [MOL File]
189699-82-9.mol | [Molecular Weight]
332.8 |
| Chemical Properties | Back Directory | [Boiling point ]
539.7±50.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-3.80±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM. | [in vivo]
Oral administration of FR-188582 (0.01-3.2 mg/kg) reverses paw edema in adjuvant arthritic rats and shows a therapeutic effect in a dose-dependent manner with ED50 values (95% C.L.) of 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively. The anti-inflammatory effect of FR-188582 (FR188582) is threefold more potent than that of Indomethacin with ED50 values (95% C.L.) of 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively[1]. | [IC 50]
COX-2: 17 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Ochi T, et al. The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats. Jpn J Pharmacol. 2001 Feb;85(2):175-82. DOI:10.1254/jjp.85.175 |
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cjbscvictory
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13348960310 |
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https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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