| Hazard Information | Back Directory | [Description]
MK-0703 is a selective cyclooxygenase-2 inhibitor investigated for the treatment of acute pain and inflammation. MK-0703 at 50 and 100 mg was shown to be efficacious in the treatment of postoperative dental pain and were indistinguishable from the active comparator, ibuprofen 400 mg. | [Uses]
COX-2-IN-36 (compound 1) is a very potent and specific COX-2 inhibitor, with an IC50 of 0.4 μM[1][2]. | [References]
[1] Lushi Tan, et al. Practical enantioselective synthesis of a COX-2 specific inhibitor. Tetrahedron
Volume 58, Issue 37, 9 September 2002, Pages 7403-7410.
[2] Yves Leblanc, et al. Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3317-20. DOI:10.1016/s0960-894x(02)00739-4 |
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