| Identification | Back Directory | [Name]
PD 168 077 MALEATE | [CAS]
190383-31-4 | [Synonyms]
077
PD168
PD-168
PD 168
pd 168,077 maleate salt
PD 168077 maleate, D4 agonist
N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide
N-[[4-(2-Cyanophenyl)-1-piperazinyl]methyl]-3-methyl-benzamide
Benzamide, N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-
N-((4-(2-CYANOPHENYL)PIPERAZIN-1-YL)METHYL)-3-METHYLBENZAMIDE MALEATE
n-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methylbenzamide maleate salt | [Molecular Formula]
C20H22N4O | [MDL Number]
MFCD01321067 | [MOL File]
190383-31-4.mol | [Molecular Weight]
334.41 |
| Chemical Properties | Back Directory | [Boiling point ]
554.6±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [solubility ]
DMSO: >10 mg/mL | [form ]
powder | [pka]
14.89±0.46(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. PD 168077 is a D4 dopamine receptor agonist and can be used to study ligand-receptor interactions of dopamine receptors (2). | [Biological Activity]
Selective D4 dopamine receptor agonist. | [in vivo]
PD-168077 (0.2-25.0 mg/kg) dose-dependently induces locomotion, which takes an unusual and characteristic ”shuffling” form with uncoordinated movements together with yawning, and episodes of myoclonic jerking; grooming, and rearing are reduced[1]. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Alfa Chemistry
|
| Tel: |
+1 (201) 478-8534 |
| Website: |
www.alfa-chemistry.com |
|