| Identification | Back Directory | [Name]
8-Br-cAMP-AM | [CAS]
190522-24-8 | [Synonyms]
8-Br-cAMP-AM
Adenosine, 8-bromo-, cyclic 3',5'-[(S)-(acetyloxy)methyl phosphate] (9CI) | [Molecular Formula]
C13H15BrN5O8P | [MOL File]
190522-24-8.mol | [Molecular Weight]
480.17 |
| Hazard Information | Back Directory | [Uses]
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury[1]. | [References]
[1] Khaliulin I, et al. Preconditioning or postconditioning with 8-Br-cAMP-AM protects the heart against regional ischemia and reperfusion: A role for mitochondrial permeability transition[J]. Cells, 2021, 10(5): 1223. DOI:10.3390/cells10051223 |
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