| Identification | Back Directory | [Name]
2-[N-(4-Chlorophenyl)-N-MethylaMino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one | [CAS]
190842-36-5 | [Synonyms]
YM 928
2-[(4-Chlorophenyl)methylamino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one
4H-Pyrido[3,2-e]-1,3-thiazin-4-one, 2-[(4-chlorophenyl)methylamino]-
2-[N-(4-Chlorophenyl)-N-MethylaMino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one | [Molecular Formula]
C14H10ClN3OS | [MDL Number]
MFCD07772337 | [MOL File]
190842-36-5.mol | [Molecular Weight]
303.767 |
| Hazard Information | Back Directory | [Uses]
YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders[1]. | [References]
[1] Ohno K, et al. Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. J Pharmacol Exp Ther. 2003 Jul;306(1):66-72. DOI:10.1124/jpet.103.049973 |
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