| Identification | Back Directory | [Name]
Remdesivir impurity | [CAS]
1911578-74-9 | [Synonyms]
Remdesivir impurity
Remdesivir Impurity 40
Remdesivir Impurity 46
Remdesivir nucleoside monophosphate
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(dihydrogen phosphate) | [Molecular Formula]
C12H14N5O7P | [MDL Number]
MFCD32708519 | [MOL File]
1911578-74-9.mol | [Molecular Weight]
371.25 |
| Hazard Information | Back Directory | [Uses]
Remdesivir nucleoside monophosphate is a metabolite of Remdesivir[1]. Remdesivir is a nucleoside analogue with effective antiviral activity against SARS-CoV and MERS-CoV[2]. | [Definition]
ChEBI: GS-441524 monophosphate is a C-nucleoside phosphate that is GS-441524 in which the 5'-hydroxy group has been replaced by a phosphate group. In cells, GS-441524 monophosphate gets converted into the pharmacologically active triphosphate form (GS-443902). It has a role as an anticoronaviral agent, an antiviral drug and a drug metabolite. It is a C-nucleoside phosphate, an aromatic amine, a nitrile and a pyrrolotriazine. It is functionally related to a GS-441524. | [References]
[1] Byoung Kwon Chun, et al. or treating filoviridae virus infections. US20160122374.
[2] Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. DOI:10.1128/mBio.00221-18 |
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