| Identification | Back Directory | [Name]
Benzamide, 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxy- | [CAS]
1912422-56-0 | [Synonyms]
NFATc1-IN-1
Benzamide, 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxy- | [Molecular Formula]
C13H8F2INO2 | [MOL File]
1912422-56-0.mol | [Molecular Weight]
375.11 |
| Chemical Properties | Back Directory | [Boiling point ]
360.8±42.0 °C(Predicted) | [density ]
1.901±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
8.03±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research[1]. | [References]
[1] Chen CL, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016 Jul 19;117:70-84. DOI:10.1016/j.ejmech.2016.04.007 |
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