| Identification | Back Directory | [Name]
2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) | [CAS]
1914148-73-4 | [Synonyms]
Ezurpimtrostat hydrochloride
2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) | [Molecular Formula]
C25H32Cl2N4 | [MOL File]
1914148-73-4.mol | [Molecular Weight]
459.46 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1]. | [in vivo]
Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1]. | [storage]
Store at -20°C | [References]
[1] Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1. |
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