| Identification | Back Directory | [Name]
1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE | [CAS]
191421-10-0 | [Synonyms]
5-NIdR
2'-DEOXY-NITRO INDOLE NUCLEOSIDE
5-Nitroindole 2'-deoxyribonucleoside
1-(b-D-2-Deoxyribofuranosyl)-5-nitroindole
1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole
1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole
1-(2-Deoxy-b-D-ribofuranosyl)-5-nitroindole
1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE
1H-Indole, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-nitro-
1-(2-Deoxy-β-D-erythro -pentofuranosyl)-5-
nitro-1H -indole
1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-nitro-1H-indole | [Molecular Formula]
C13H14N2O5 | [MDL Number]
MFCD01631019 | [MOL File]
191421-10-0.mol | [Molecular Weight]
278.26 |
| Chemical Properties | Back Directory | [Boiling point ]
572.5±50.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
14.01±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1]. | [in vivo]
5-NIdR (100 mg/kg; ip; for 5 consecutive days), together with Temozolomide (40 mg/kg), results complete tumor regression in a murine xenograft model of glioblastoma. Temozolomide alone only delayed tumor growth[1].
| [References]
[1] Choi JS, et al. Inhibition of Translesion DNA Synthesis as a Novel Therapeutic Strategy to Treat Brain Cancer. Cancer Res. 2018 Feb 15;78(4):1083-1096. DOI:10.1158/0008-5472.CAN-17-2464 |
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BOC Sciences
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