| Identification | Back Directory | [Name]
PHGDH-inactive | [CAS]
1914971-16-6 | [Synonyms]
PHGDH-inactive
NCT-503 Inactive Control >=98% (HPLC)
N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-1-piperazinecarbothioamide
1-Piperazinecarbothioamide, N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)- | [Molecular Formula]
C17H21N5S | [MDL Number]
MFCD30343877 | [MOL File]
1914971-16-6.mol | [Molecular Weight]
327.45 |
| Chemical Properties | Back Directory | [Boiling point ]
497.9±55.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMF: 2 mg/mL; DMSO: 5 mg/mL; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL | [form ]
A crystalline solid | [pka]
12.96±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
PHGDH-inactive is an inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503. PHGDH-inactive is intended to serve as a negative control for NCT-502 and NCT-503. | [Uses]
PHGDH-inactive has no activity against PHGDH and serves as a negative control of NCT-502 and NCT-503[1]. | [storage]
4°C, protect from light | [References]
[1] Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8):656]. Nat Chem Biol. 2016;12(6):452-458. DOI:10.1038/nchembio.2070 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|