| Identification | Back Directory | [Name]
BRD-IN-26 | [CAS]
1915012-19-9 | [Synonyms]
BRD-IN-26
Pyrrolo[1,2-a]quinazolin-5(1H)-one, 6-chloro-2,3-dihydro-3-[(4-methyl-1-piperazinyl)methylene]-, (3E)- | [Molecular Formula]
C17H19ClN4O | [MOL File]
1915012-19-9.mol | [Molecular Weight]
330.81 |
| Hazard Information | Back Directory | [Uses]
SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1(5), SMARCA2B and SMARCA4 with Kd of 124, 262 and 417 nM[1]. | [References]
[1] Sutherell CL, et al., Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex. J Med Chem. 2016 May 26;59(10):5095-101. DOI:10.1021/acs.jmedchem.5b01997 |
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