| Identification | Back Directory | [Name]
Pyrrolo[1,2-a]quinazolin-5(1H)-one, 6-chloro-3-(2-ethylbutylidene)-2,3-dihydro-, (3E)- | [CAS]
1915012-21-3 | [Synonyms]
PBRM1-BD2-IN-1
Pyrrolo[1,2-a]quinazolin-5(1H)-one, 6-chloro-3-(2-ethylbutylidene)-2,3-dihydro-, (3E)- | [Molecular Formula]
C17H19ClN2O | [MOL File]
1915012-21-3.mol | [Molecular Weight]
302.8 |
| Hazard Information | Back Directory | [Uses]
PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer[1]. | [References]
[1] Shifali Shishodia, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13. DOI:10.1021/acs.jmedchem.2c00864 |
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