| Identification | Back Directory | [Name]
SIB 1553A hydrochloride | [CAS]
191611-89-9 | [Synonyms]
SIB 1553A hydrochloride
SIB 1553A Hyrdrochloride
4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol
4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride
(±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride | [Molecular Formula]
C13H20ClNOS | [MOL File]
191611-89-9.mol | [Molecular Weight]
273.82 |
| Chemical Properties | Back Directory | [Melting point ]
149-151°C | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Description]
SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors. Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals. | [Uses]
SIB 1553A hyrdrochloride is a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors (nAChR). | [in vivo]
SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3]. | Animal Model: | Male Sprague-Dawley rats (200-250 g)[3] | | Dosage: | 1, 2, 4, 10, 20 and 40 mg/kg | | Administration: | s.c. | | Result: | Induced hippocampal ACh release. |
| [storage]
Store at -20°C | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] J S SCHNEIDER. The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 306 1: 401-406. DOI: 10.1124/jpet.103.051912
[3] TERRY A, RISBROUGH V, BUCCAFUSCO J, et al. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 264 1: 0. DOI: 10.1124/jpet.301.1.284 |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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