| Identification | Back Directory | [Name]
Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) | [CAS]
19178-25-7 | [Synonyms]
Pyrido[3.4-d]pyrimidin-4-ol
Pyrido[3,4-d]pyriMidin-4-one
Pyrido[3,4-d]pyrimidin-4(3H)
1H-pyrido[3,4-d]pyrimidin-4-one
3H-Pyrido[3,4-d]pyrimidin-4-one
Pyrido[3,4-d]pyriMidin-4(3H)-one
3H,4H-Pyrido[3,4-d]pyrimidin-4-one
3,4-Dihydropyrido[3,4-d]pyrimidin-4-one
Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI)
Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) ISO 9001：2015 REACH | [Molecular Formula]
C7H5N3O | [MDL Number]
MFCD09999183 | [MOL File]
19178-25-7.mol | [Molecular Weight]
147.13 |
| Chemical Properties | Back Directory | [Melting point ]
305℃ | [Boiling point ]
346.2±34.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
2.95±0.20(Predicted) | [Appearance]
Light brown to gray Solid |
| Hazard Information | Back Directory | [Synthesis]
3-Aminoisonicotinic acid (691 mg, 5.0 mmol), formamidine acetate (573 mg, 5.5 mmol) and anhydrous ethanol (10 mL) were added to a Biotage microwave reactor tube. The reaction mixture was placed in a microwave reactor and heated at 160 °C for 30 min. After completion of the reaction, the reaction solution was diluted with deionized water (20 mL) and cooled to 0 °C in an ice bath. The resulting suspension was extracted and the filter cake was washed with ice-cooled deionized water (10 mL) to afford quinazoline A2 (259 mg, 35% yield) in white solid form. The product was analyzed by LC-MS showing purity >98% (m/z = 148.0 [M + H]+, retention time Rt = 0.604 min). | [References]
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[2] Patent: WO2014/179237, 2014, A1. Location in patent: Paragraph 00491 |
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| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
NovoChemy Ltd.
|
| Tel: |
021-31261262/ 49 (0)17662837245 |
| Website: |
www.novochemy.com |
|