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191786-64-8

191786-64-8 Structure

191786-64-8 Structure
IdentificationBack Directory
[Name]

5’-O-DMTr-2’-OMeU-methyl phosphonamidite
[CAS]

191786-64-8
[Synonyms]

5’-O-DMTr-2’-OMeU-methylphosphonamidite
5’-O-DMTr-2’-OMeU-methyl phosphonamidite
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphomidite
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite] (9CI)
5’-O-DMTr-2’-OMeU-methyl phosphonamidite, 5’-O-DMTr-2’-O-methyluridine-3’-O-(P-methyl-N,N-diisopropylamino) phosphonamidite
[Molecular Formula]

C38H48N3O8P
[MOL File]

191786-64-8.mol
[Molecular Weight]

705.79
Chemical PropertiesBack Directory
[pka]

9.39±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

5’-O-DMTr-2’-OMeU-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
[References]

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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