| Identification | Back Directory | [Name]
BMS-986205 | [CAS]
1923833-60-6 | [Synonyms]
CS-2743
BMS-986205
Linrodostat
BMS 986205;BMS986205
BMS-986205(Linrodostat)
LINRODOSTAT;BMS 986205;BMS986205
(2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamid
Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-α-methyl-, cis-(αR)- | [Molecular Formula]
C24H24ClFN2O | [MDL Number]
MFCD31619233 | [MOL File]
1923833-60-6.mol | [Molecular Weight]
410.91 |
| Chemical Properties | Back Directory | [Boiling point ]
606.8±45.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM) | [form ]
Solid | [pka]
13.80±0.70(Predicted) | [color ]
White to off-white | [InChI]
InChI=1/C24H24ClFN2O/c1-15(24(29)28-20-9-6-18(25)7-10-20)16-2-4-17(5-3-16)21-12-13-27-23-11-8-19(26)14-22(21)23/h6-17H,2-5H2,1H3,(H,28,29)/t15-,16?,17?/s3 | [InChIKey]
KRTIYQIPSAGSBP-YQHGZOAXNA-N | [SMILES]
C(NC1=CC=C(Cl)C=C1)(=O)[C@@H](C1CCC(C2=C3C(=NC=C2)C=CC(F)=C3)CC1)C |&1:10,r| |
| Hazard Information | Back Directory | [Biological Activity]
Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays. | [Description]
BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. | [Uses]
BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders. | [IC 50]
IDO1: 1.1 nM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
DKMbiochem.Co. Ltd
|
| Telephone: |
15901859516 |
| Website: |
http://www.dkmbiochem.com/ |
| Company Name: |
Hui Chem Co., Ltd.
|
| Telephone: |
021-34799779 18918539052 |
| Website: |
http://www.huichem.com |
|