| Identification | Back Directory | [Name]
2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- | [CAS]
192384-87-5 | [Synonyms]
2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-
inhibit,BP-897,BP897,cocaine drug-seeking,BP 897,Dopamine Receptor,Inhibitor,addiction,behaviour,motivational,stimuli,rewarding | [Molecular Formula]
C26H31N3O2 | [MDL Number]
MFCD04039996 | [MOL File]
192384-87-5.mol | [Molecular Weight]
417.54 |
| Hazard Information | Back Directory | [Uses]
BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM)[1]. | [Definition]
ChEBI: N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide is a naphthalenecarboxamide. | [in vivo]
| Animal Model: | Male Listar hooded rats[1] | | Dosage: | 0.05, 0.5, 1 mg/kg | | Administration: | i.p.; 30 min before the session | | Result: | Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
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| [IC 50]
D2 Receptor; D3 Receptor | [References]
[1] Pilla M, et al. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist [published correction appears in Nature 1999 Sep 23;401(6751):403]. Nature. 1999;400(6742):371-375. DOI:10.1038/22560 |
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