| Identification | Back Directory | [Name]
NEOTROFIN | [CAS]
192564-13-9 | [Synonyms]
SPI205
SPI-205
SPI 205
NEOTROFIN
Leteprinim potassium
Leteprinim Potassium Salt
Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate
4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid
4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt
Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-, potassium salt (1:1) | [Molecular Formula]
C15H12N5O4.K | [MDL Number]
MFCD09763657 | [MOL File]
192564-13-9.mol | [Molecular Weight]
365.389 |
| Hazard Information | Back Directory | [Chemical Properties]
Off White to Pale Yellow Solid | [Uses]
A synthetic purine derivative with neuroprotective effects. A cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism. | [Brand name]
Neotrofin (NeoTherapeutics). | [in vivo]
Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4]. | Animal Model: | Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4] | | Dosage: | 60 mg/kg | | Administration: | IP; single dosage | | Result: | The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.
In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline. |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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