| Identification | Back Directory | [Name]
PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2 | [CAS]
1926163-16-7 | [Synonyms]
Triptorelin-Leu-Arg-Pro-Gly-NH2
(D-TRP6)-LHRH-LEU-ARG-PRO-GLY NH2
TRIPTORELIN-LEU-ARG-PRO-GLY AMIDE
(D-TRP6)-LHRH-LEU-ARG-PRO-GLY AMIDE
PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2
(D-TRP6)-GONADOTROPIN-RELEASING HORMONE-LEU-ARG-PRO-GLY AMIDE
(D-TRP6)-LUTEINIZING HORMONE-RELEASING FACTOR-LEU-ARG-PRO-GLY AMIDE
(D-TRP6)-LUTEINIZING HORMONE-RELEASING HORMONE-LEU-ARG-PRO-GLY AMIDE | [Molecular Formula]
C83H115N25O17 | [MDL Number]
MFCD03093474 | [MOL File]
1926163-16-7.mol | [Molecular Weight]
1734.96 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
9.82±0.15(Predicted) | [Sequence]
{Pyr}-His-Trp-Ser-Tyr-{d-Trp}-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH2 |
| Hazard Information | Back Directory | [Uses]
(D-Trp6)-LHRH-Leu-Arg-Pro-Gly amide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. | [Biological Activity]
Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH2 ([D-Trp6]-LH-RH-Leu-Arg-Pro-Gly-NH2) is a GnRH (gonadotropin-releasing hormone) agonisttriptorelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2)which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelinis crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropinsluteinizing hormone (LH) and follicle-stimulating hormone (FSH)from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Triptorelin is used for the treatment of hormone-associated prostate and breast cancersendometriosisuterine fibroidscentral precocious puberty and in vi | [References]
[1] Birnbaum S, et al. Peptide screening. Current Opinion in Biotechnology, 1992, 3(1): 49-54. |
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