| Identification | Back Directory | [Name]
CNGRCGGKLAKLAKKLAKLAK-NH2 (DISULFIDE BRIDGE: 1-5) | [CAS]
1926163-30-5 | [Synonyms]
NGR PEPTIDE 1
CNGRCGGKLAKLAKKLAKLAK-NH2
TUMOR TARGETED PRO-APOPTOTIC PEPTIDE
CNGRC-GG-(KLAKLAK)2-NH2 (DISULFIDE BOND)
CNGRCGGKLAKLAKKLAKLAK-NH2 (DISULFIDE BOND)
CNGRCGGKLAKLAKKLAKLAK-NH2 (DISULFIDE BRIDGE: 1-5)
CNGRCGGklaklakklaklak-NH2 (Disulfide bond), CNGRC-GG-(klaklak)2-NH2 (Disulfide bond)
CYS-ASN-GLY-ARG-CYS-GLY-GLY-DLYS-DLEU-DALA-DLYS-DLEU-DALA-DLYS-DLYS-DLEU-DALA-DLYS-DLEU-DALA-DLYS
H-CYS-ASN-GLY-ARG-CYS-GLY-GLY-D-LYS-D-LEU-D-ALA-D-LYS-D-LEU-D-ALA-D-LYS-D-LYS-D-LEU-D-ALA-D-LYS-D-LEU-D-ALA-D-LYS-NH2
H-CYS-ASN-GLY-ARG-CYS-GLY-GLY-D-LYS-D-LEU-D-ALA-D-LYS-D-LEU-D-ALA-D-LYS-D-LYS-D-LEU-D-ALA-D-LYS-D-LEU-D-ALA-D-LYS-NH2 (DISULFIDE BRIDGE: 1-5) | [Molecular Formula]
C94H176N32O22S2 | [MDL Number]
MFCD06796021 | [MOL File]
1926163-30-5.mol | [Molecular Weight]
2170.73 |
| Hazard Information | Back Directory | [Uses]
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1]. | [in vivo]
Tumor targeted pro-apoptotic peptide inhibits both primary tumor growth and metastasis in mice[1]. | Animal Model: | Tumor targeted pro-apoptotic peptide (250 μg/mice; tail vein injection; 250 μg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1]. | | Dosage: | 250 μg/mice | | Administration: | Tail vein injection; 250 μg a week for 17 weeks | | Result: | Exhibited antitumor activity in vivo. |
| [References]
[1] Ellerby HM, et al. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med. 1999 Sep;5(9):1032-8. DOI:10.1038/12469 |
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