| Identification | Back Directory | [Name]
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt | [CAS]
1926163-57-6 | [Synonyms]
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]- | [Molecular Formula]
C31H49FN10O6 | [MDL Number]
MFCD12964270 (net) | [MOL File]
1926163-57-6.mol | [Molecular Weight]
676.78 |
| Hazard Information | Back Directory | [Uses]
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity[1]. | [in vivo]
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (37.5 M*0.2 mL; every other day for 12 days) inhibits the growth of the tumor in mouse[1]. | Animal Model: | 4-6 weeks, 16-20 g, Female BALB/c nude mice (OCI-LY10 cells)[1] | | Dosage: | 37.5 M*0.2 mL | | Administration: | Every other day for 12 days | | Result: | Inhibited the growth of the xenografts and decreased the expression of P65. |
| [References]
[1] Feng J, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. PMID:31934017 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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