| Identification | Back Directory | [Name]
GNE-371 | [CAS]
1926986-36-8 | [Synonyms]
GNE-371
GNE 371,GNE371
7H-Pyrrolo[2,3-c]pyridin-7-one, 6-(3-buten-1-yl)-1,6-dihydro-4-[1-methyl-6-(4-morpholinylcarbonyl)-1H-benzimidazol-4-yl]- | [Molecular Formula]
C24H25N5O3 | [MDL Number]
MFCD31735116 | [MOL File]
1926986-36-8.mol | [Molecular Weight]
431.49 |
| Chemical Properties | Back Directory | [Boiling point ]
737.1±70.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
15.66±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). | [References]
[1] Wang S, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem. 2018 Oct 25;61(20):9301-9315. DOI:10.1021/acs.jmedchem.8b01225 |
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