| Identification | Back Directory | [Name]
MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 | [CAS]
192723-42-5 | [Synonyms]
MCA-PLAQAV(DPA)RSSSR-NH2
MCA-PLAQAVDAP(DNP)RSSSR-NH2
Mca-PLAQAVDap(Dnp)RSSRSR-NH2
TACE SUBSTRATE II, FLUOROGENIC
FLUORESCENT PEPTIDE SUBSTRATE III
ADAM-17 SUBSTRATE II, FLUOROGENIC
TNF-ALPHA CONVERTASE ENZYME SUBSTRATE, FLUOROGENIC
Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)
MCA-(ENDO-1A-DAP(DNP))-TNF-A (-5 TO +6) AMIDE (HUMAN)
MCA-PRO-LEU-ALA-GLN-ALA-VAL-DPA-ARG-SER-SER-SER-ARG-NH2
MCA-(ENDO-1A-DAP(DNP))-TNF-ALPHA (-5 TO +6) AMIDE (HUMAN)
MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2
MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(DNP)-ARG-SER-SER-SER-ARG-NH2 USP/EP/BP
MCA-(ENDO-1A-DAP(DNP))-TUMOR NECROSIS FACTOR-ALPHA (-5 TO +6) AMIDE (HUMAN)
L-Argininamide,1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl-
L-Argininamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl- (9CI) | [Molecular Formula]
C69H103N23O24 | [MDL Number]
MFCD01318847 | [MOL File]
192723-42-5.mol | [Molecular Weight]
1638.7 |
| Chemical Properties | Back Directory | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
12.49±0.46(Predicted) | [Sequence]
{Mca}-Pro-Leu-Ala-Gln-Ala-Val-{Dpa}-Arg-Ser-Ser-Ser-Arg-NH2 |
| Hazard Information | Back Directory | [Uses]
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis[1]. | [IC 50]
ADAM10; ADAM17 | [References]
[1] Yi Wang, et al. Protease assay method using site-specific fluorescence dye labeled protein as substrate. US9708638. 2017.
[2] Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5. DOI:10.1016/j.antiviral.2009.12.001
[3] Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6. DOI:10.1038/jid.2011.462
[4] Liang T, et al. KID24, an antibody directed against ADAM9, is a potent inhibitor of tumor growth in vivo[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): C32-C32. |
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