| Identification | Back Directory | [Name]
L791943 | [CAS]
192767-01-4 | [Synonyms]
L791943
Benzenemethanol, 4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxido-4-pyridinyl)ethyl]-α,α-bis(trifluoromethyl)- | [Molecular Formula]
C24H17F10NO4 | [MDL Number]
MFCD31544402 | [MOL File]
192767-01-4.mol | [Molecular Weight]
573.38 |
| Chemical Properties | Back Directory | [Boiling point ]
561.6±50.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.17±0.15(Predicted) |
| Hazard Information | Back Directory | [Uses]
L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM. | [IC 50]
PDE4 | [References]
[1] Richard Frenette, et al. Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13. DOI:10.1016/s0960-894x(02)00615-7
[2] Guay D, et al. Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. DOI:10.1016/s0960-894x(02)00190-7 |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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