| Identification | Back Directory | [Name]
F-901318 1928707-56-5 | [CAS]
1928707-56-5 | [Synonyms]
Olorofim
F-901318
(Olorofim
F-901318 1928707-56-5
1H-Pyrrole-2-acetamide, N-[4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl]-1,5-dimethyl-α-oxo-3-phenyl-
2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-
fluoropyrimidin-2-yl)piperazin-1-yl]phenyl}-2-oxoa
cetamide | [Molecular Formula]
C28H27FN6O2 | [MDL Number]
MFCD32204761 | [MOL File]
1928707-56-5.mol | [Molecular Weight]
498.55 |
| Hazard Information | Back Directory | [Uses]
Olorofim is a novel dihyroorotate dehydrogenase enzyme inhibitor. Olorofim is a novel antifungal agent with in vitro activity against Aspergillus and other opportunistic molds. | [in vivo]
Olorofim (15 mg/kg, ip, every 8 hours for 9 days) ameliorates chronic granulomatous disease (CGD), exhibits anti-infectious activity in Aspergillus-infected mouse models[3]. | Animal Model: | Aspergillus-infected mouse models[3] | | Dosage: | 15 mg/kg | | Administration: | ip, every 8 hours for 9 days | | Result: | Reduced granulomas and fungal hyphae in the lungs. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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