| Identification | Back Directory | [Name]
CaproMorelin Tartrate | [CAS]
193273-69-7 | [Synonyms]
CS-2136
CP 424391-18
CP-424391 tartrate
CaproMorelin Tartrate
CP 424391-18; CP-424391 TARTRATE
N-{2-[(3aS)-3a-benzyl-2-methyl-3-methylidene-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-1-(benzyloxy)-2-oxoethyl}-2-methylalaninamide 2,3-dihydroxybutanedioate (1:1) | [Molecular Formula]
C32H41N5O10 | [MOL File]
193273-69-7.mol | [Molecular Weight]
655.695 |
| Chemical Properties | Back Directory | [Melting point ]
>150oC (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Light Yellow | [Water Solubility ]
H2O: 20mg/mL, clear | [Stability:]
Hygroscopic | [InChIKey]
MJGRJCMGMFLOET-GTNBBHPYNA-N | [SMILES]
[C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C(C1C=CC=CC=1)[C@]12C(N(C)N=C1CCN(C(=O)[C@H](NC(=O)C(N)(C)C)COCC1C=CC=CC=1)C2)=O |&1:0,5,17,28,r| |
| Hazard Information | Back Directory | [Uses]
Treatment
and prevention of frailty; treatment of congestive
heart failure; treatment of catabolic illness (growth
hormone secretagogue). | [Biological Activity]
Capromorelin tartrate is a potent ghrelin receptor agonist/growth hormone secretagogue (Ki = 7 nM). In r at pituitary cellsCapromorlelin incudes growth hormone (GH) secretion with an EC50 of 3 nM. Capromorelin also increases gastric motility and has been studied recently in patients with spinal cord injuries. | [in vivo]
Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group[1]. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][2]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv[2]. | [storage]
Store at -20°C |
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