| Identification | Back Directory | [Name]
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride | [CAS]
193356-17-1 | [Synonyms]
184833
1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-
Co 101244 hydrochloride (also known as PD 174494 and Ro 63-1908)
1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol hydrochloride
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride | [Molecular Formula]
C21H28ClNO3 | [MOL File]
193356-17-1.mol | [Molecular Weight]
377.905 |
| Chemical Properties | Back Directory | [Melting point ]
133-135 °C | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in water and to 50 mM in DMSO | [form ]
Powder | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50values are 0.043, > 100 and > 100μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effectsin vivoandin vitro. | [Uses]
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1]. | [in vivo]
Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1]. | [storage]
Store at +4°C | [References]
[1] Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. DOI:10.1073/pnas.0903546106 |
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