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193611-67-5

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193611-67-5 Structure

193611-67-5 Structure
IdentificationBack Directory
[Name]

N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
[CAS]

193611-67-5
[Synonyms]

SB 216641A
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
[Molecular Formula]

C28H31ClN4O4
[MOL File]

193611-67-5.mol
[Molecular Weight]

523.03
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

DMSO: soluble; Water: soluble
[form ]

Powder
[color ]

White to off-white
[Water Solubility ]

Soluble to 50 mM in water
[InChIKey]

JPBMDMNORXKGHZ-UHFFFAOYSA-N
[SMILES]

CC1C=C(C2=NOC(C)=N2)C=CC=1C1C=CC(C(=O)NC2C=CC(OC)=C(OCCN(C)C)C=2)=CC=1.Cl
Hazard InformationBack Directory
[Uses]

SB 216641 Hydrochloride is a selective SR-1B and 5-HT1B antagonist.
[in vivo]

SB-216641A (0.6-20 mg/kg; i.p.; single dose) hinders the SKF-99101H induced hypothermia with dose-dependent manner in guinea pigs[1].
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2].

Animal Model:Guinea pigs[1].
Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.
Administration:Intraperitoneal injection; single dose.
Result:Significantly blocked the effects of SKF-99101H.
Animal Model:Dogs[2].
Dosage:559 nmol/kg.
Administration:Intravenous injection; single dose.
Result:Improved the gastric relaxation.
[IC 50]

5-HT1B Receptor; 5-HT1D Receptor
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3(193611-67-5)1HNMR
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