| Identification | Back Directory | [Name]
Bis-PEG2-acid | [CAS]
19364-66-0 | [Synonyms]
Bis-PEG2-acid
Bis-PEG2-COOH
COOH-PEG1-COOH
HOOCCH2CH2O-PEG1-CH2CH2COOH
1,2-Bis(2-carboxyethoxy)ethane
3-[2-(2-carboxyethoxy)ethoxy]propanoic acid
3,3'-[ethane-1,2-diylbis(oxy)]dipropanoic acid
Propanoic acid, 3,3'-[1,2-ethanediylbis(oxy)]bis- | [Molecular Formula]
C8H14O6 | [MDL Number]
MFCD22056315 | [MOL File]
19364-66-0.mol | [Molecular Weight]
206.19 |
| Chemical Properties | Back Directory | [Melting point ]
66 °C | [Boiling point ]
407.1±35.0 °C(Predicted) | [density ]
1.0869 g/cm3(Temp: 4 °C) | [solubility ]
Soluble in Water, DMF, DMSO | [form ]
Solid | [pka]
3.97±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bis-PEG2-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. DOI:10.1021/acs.jmedchem.9b01264 |
|
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|