| Chemical Properties | Back Directory | [Boiling point ]
532.5±35.0 °C(Predicted) | [density ]
1.016±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3mg/ml; DMSO: 20 mg/ml; Ethanol: 15 mg/ml | [form ]
A crystalline solid | [pka]
3.51±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs).1 Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM.1 | [Uses]
Commendamide is a GPCR G2A/GPR132 agonist (EC50: 11.8 μM). Commendamide can be used for research of autoimmunity and atherosclerosis[1]. | [Definition]
ChEBI: N-(3-Hydroxy-1-oxohexadecyl)-glycine is a N-acyl-amino acid. | [References]
1. Cohen, L.J., Kang, H.S., Chu, J., et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist Proc. Natl. Acad. Sci. USA 112(35),E4825-E4834(2015). |
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