| Identification | Back Directory | [Name]
Cortistatin 14 | [CAS]
193829-96-8 | [Synonyms]
CST-14, human, rat
Cortistatin 14, human, rat(Synonyms: CST-14, human, rat) | [Molecular Formula]
C81H113N19O19S2 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 0.70 mg/ml in water | [Sequence]
Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (Disulfide bridge: Cys2-Cys13) |
| Hazard Information | Back Directory | [Uses]
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2]. | [storage]
Desiccate at -20°C | [References]
[1] Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767. DOI:10.3389/fphar.2018.00767
[2] de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. DOI:10.1038/381242a0 |
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