| Identification | Back Directory | [Name]
Dot1L-IN-2 | [CAS]
1940206-71-2 | [Synonyms]
Dot1L-IN-2
2,4-Pyrimidinediamine, N4-methyl-N2-[2-methyl-1-[2-[(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)oxy]phenyl]-1H-indol-6-yl]- | [Molecular Formula]
C27H24N8O | [MDL Number]
MFCD31692365 | [MOL File]
1940206-71-2.mol | [Molecular Weight]
476.53 |
| Chemical Properties | Back Directory | [Boiling point ]
681.6±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
6.81±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. | [storage]
Store at -20°C | [References]
[1] Chen C, et al. Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Med Chem Lett. 2016 Jun 1;7(8):735-40. DOI:10.1021/acsmedchemlett.6b00167 |
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| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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