| Identification | Back Directory | [Name]
CAY10719 | [CAS]
1942919-63-2 | [Synonyms]
CAY10719
Methanone, [1-(3,4-dichlorophenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl](4-methoxyphenyl)- | [Molecular Formula]
C25H20Cl2N2O2 | [MOL File]
1942919-63-2.mol | [Molecular Weight]
451.34 |
| Chemical Properties | Back Directory | [Boiling point ]
657.1±55.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 2 mg/ml | [form ]
A crystalline solid | [pka]
16?+-.0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 μM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPase activity. | [Uses]
ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 μM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity[1]. | [storage]
Store at -20°C | [References]
[1] Spindler A, et al., Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2). J Med Chem. 2016 Jul 14;59(13):6121-35. DOI:10.1021/acs.jmedchem.6b00035 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|