| Identification | Back Directory | [Name]
5α-Cholesta-8,14-dien-3β-ol | [CAS]
19431-20-0 | [Synonyms]
Δ8,14-Cholestadienol
14-dehydro Zymostenol
5α-Cholesta-8,14-dien-3β-ol
(3β,5α)-Cholesta-8,14-dien-3-ol
14 dehydro Zymostenol,14dehydro Zymostenol | [Molecular Formula]
C27H44O | [MDL Number]
MFCD28359036 | [MOL File]
19431-20-0.mol | [Molecular Weight]
384.638 |
| Chemical Properties | Back Directory | [Melting point ]
116-117 °C(Solv: methanol (67-56-1)) | [Boiling point ]
498.6±44.0 °C(Predicted) | [density ]
1.00±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 3 mg/ml,Ethanol: 2 mg/ml | [form ]
A crystalline solid | [pka]
15.11±0.70(Predicted) | [InChIKey]
AWBZPJQUWZBRII-BTEGJBIDSA-N | [SMILES]
C[C@]1(CC2)C(C3=C2[C@]4(C)C(CC3)C[C@@H](O)CC4)=CCC1C(CCCC(C)C)C |
| Hazard Information | Back Directory | [Description]
14-dehydro Zymostenol is a precursor to cholesterol . It increases the percentage of myelin basic protein-positive (MBP+) oligodendrocytes formed from oligodendrocyte precursor cells when used at concentrations of 5.8 and 17 μM. | [Uses]
(3β,5α)-Cholesta-8,14-dien-3-ol is a human cholesterol derivative. | [Definition]
ChEBI: 5alpha-cholesta-8,14-dien-3beta-ol is a 3beta-sterol that is 5alpha-cholestane-3beta-ol having double bonds at the 8,9- and 14,15- positions. It derives from a hydride of a 5alpha-cholestane. | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ZITA HUBLER. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination[J]. Nature, 2018, 560 7718: 372-376. DOI: 10.1038/s41586-018-0360-3 |
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Merck KGaA
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