| Identification | Back Directory | [Name]
4-[(3-BROMOPHENYL)AMINO]-6-ACRYLAMIDOQUINAZOLINE | [CAS]
194423-15-9 | [Synonyms]
CS-2316
PD 168393
PD168393 USP/EP/BP
PD-168393;PD 168393
PD168393;PD-168393;PD 168393
4-[(3-BROMOPHENYL)AMINO]-6-ACRYLAMIDOQUINAZOLINE
N-[4-(3-Bromoanilino)quinazolin-6-yl]prop-2-enamide
N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)acrylamide
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide
2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- | [Molecular Formula]
C17H13BrN4O | [MDL Number]
MFCD02179207 | [MOL File]
194423-15-9.mol | [Molecular Weight]
369.22 |
| Chemical Properties | Back Directory | [Melting point ]
279℃ | [Boiling point ]
571.1±50.0 °C(Predicted) | [density ]
1.558±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
insoluble in H2O; ≥1 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.45 mg/mL in DMSO | [form ]
powder | [pka]
12.19±0.43(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Potent, cell permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50=700pM). Antitumor agent in vivo. | [Definition]
ChEBI: A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively. | [Biochem/physiol Actions]
PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction. | [Enzyme inhibitor]
This photosensitive quinazoline (FW = 369.22 g/mol), also known as 4-[ (3-
bromophenyl) amino]-6-acrylamido-quinazoline, irreversibly inhibits
epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.7
nM. See also PD 174265 | [target]
EGFR |
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