| Identification | Back Directory | [Name]
(aS)-a-chloro-benzenepropanoic acid sodium salt | [CAS]
194979-70-9 | [Synonyms]
(S)-CPP sodium salt
(S)-CPP sodium salt >=96% (HPLC)
(aS)-a-chloro-benzenepropanoic acid sodium salt
(S)-2-Chloro-3-phenylpropanoic acid sodium salt | [Molecular Formula]
C9H10ClNaO2 | [MDL Number]
MFCD28118980 | [MOL File]
194979-70-9.mol | [Molecular Weight]
208.62 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 20mg/mL, clear | [InChI]
1S/C9H9ClO2.Na/c10-8(9(11)12)6-7-4-2-1-3-5-7;/h1-5,8H,6H2,(H,11,12);/q;+1/p-1/t8-;/m0./s1 | [InChIKey]
HMHPCHNNVOLTFC-QRPNPIFTSA-M | [SMILES]
[O-]C([C@@H](Cl)CC1=CC=CC=C1)=O.[Na+] |
| Hazard Information | Back Directory | [Uses]
(S)-CPP sodium serves as an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, the inhibition of BDK by (S)-CPP (with an IC50 of 6.3 μM) results in the activation of the complex and a notable decrease in plasma levels of leucine/isoleucine and valine in wild-type mice. | [Biological Activity]
(S)-CPP is an inhibitor of branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinasealso know as BDKor keto acid dehydrogenase kinase. BDK is a negative regulator of BCKDC activity. Inhibition of BDK by (S)-CPP (IC50 = 6.3 μM) leads to complex activationand significant reduction of plasma levels of leucine/isoleucine and valine in wild type mice. | [References]
[1] Erne, D., et al.Helvetica Chimica Acta1980
[2] Paper-Based Electronic Tongue |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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Merck KGaA
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www.sigmaaldrich.cn |
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