| Chemical Properties | Back Directory | [Boiling point ]
831.7±65.0 °C(Predicted) | [density ]
1.287±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.48±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Cleavable Linker | [References]
[1] Wayne C Widdison, et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. Bioconjug Chem. 2015 Nov 18;26(11):2261-78. DOI:10.1021/acs.bioconjchem.5b00430 |
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