| Hazard Information | Back Directory | [Description]
YF-452 is a novel inhibitor of tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. | [Uses]
YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research[1]. | [IC 50]
VEGFR2 | [References]
[1] Liu Y, et al. A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. Sci China Life Sci. 2017 Feb;60(2):202-214. DOI:10.1007/s11427-016-0369-6 |
|
|