| Identification | Back Directory | [Name]
PF-06748962 | [CAS]
1952261-87-8 | [Synonyms]
PF-06748962
PF-06748962 >=98% (HPLC)
2(1H)-Pyridinone, 3-[(3R)-3-methyl-2-oxo-3-piperidinyl]-6-(5-methyl-3-quinolinyl)- | [Molecular Formula]
C21H21N3O2 | [MOL File]
1952261-87-8.mol | [Molecular Weight]
347.41 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Optical Rotation]
[α]/D -880 to -920°, c = 0.5 in chloroform-d | [SMILES]
CC1=CC=CC2=NC=C(C3=CC=C([C@]4(C)C(NCCC4)=O)C(N3)=O)C=C21 |
| Hazard Information | Back Directory | [Uses]
EP3 antagonist 2 (Compound Exp 1) is a potent and selective EP3 receptor antagonist. EP3 antagonist 2 has a strong binding affinity for the human EP3 receptor (Ki: 3.3 nM) and significant antagonistic activity (IC50: 30.8 nM, determined by cellular cAMP levels)[1]. | [Biological Activity]
PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist. | [References]
[1] Kevin Bahnck, et al. Antagonists of prostaglandin ep3 receptor. US20160176851A1. 2016-06-23. |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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